Affecting the entire body (8)
I believe the answer is:
systemic
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">affecting the entire body</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this in another clue)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for systemic that I've seen before include "City mess (anag)" , "My sect is concerned with affecting the whole body" , "insecticide" , "Relating to the whole organism" , "Affecting a body, institution, etc as a whole" .)