Anne is flipping mad (6)
I believe the answer is:
insane
'mad' is the definition.
(similar in meaning)
'anne is flipping' is the wordplay.
'flipping' indicates anagramming the letters (I've seen 'flips' mean this).
'anne'+'is'='anneis'
'anneis' anagrammed gives 'INSANE'.
(Other definitions for insane that I've seen before include "out to lunch" , "without any reason" , "Anne is (anag) - crazy" , "mad for love?" , "Quite mad" .)