Both hands cradling mellow brew (5)
I believe the answer is:
lager
'brew' is the definition.
(lager is a kind of brew)
'both hands cradling mellow' is the wordplay.
'both hands' becomes 'LR' (abbreviation for left and right).
'cradling' means one lot of letters goes inside another.
'mellow' becomes 'age' (both can mean to mature).
'lr' enclosing 'age' is 'LAGER'.
(Other definitions for lager that I've seen before include "Type of beer" , "Tipple" , "light ale" , "Light beer; sounds like camp" , "Regal sort of beer" .)