Drive up the wall (3)
I believe the answer is:
vex
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">drive up the wall</span>' is the definition.<br/ ><span class="explanation-format__explanation">(thesaurus)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for vex that I've seen before include "upset" , "Irk" , "Irritate, annoy" .)