Drug Republican from Rome, possibly, ignoring American (7)
I believe the answer is:
ritalin
'drug' is the definition.
(I've seen this before)
'republican from rome possibly ignoring american' is the wordplay.
I cannot quite see how this works, but
'republican' could be 'r' (abbreviation in US politics) and 'r' is found within the answer.
'from' could be 'in' (I've seen this in other clues) and 'in' is found in the answer.
'american' could be 'a' (common abbreviation - e.g. in organisation names) and 'a' is found in the answer.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for ritalin that I've seen before include "stimulant" , "Drug" .)