Escape from a scuffle, exhausted (4)
I believe the answer is:
flee
'escape' is the definition.
(I've seen this in another clue)
'from a scuffle exhausted' is the wordplay.
'from' says the answer is hidden in the clue.
'FLEE' is hidden in the letters of 'scuffle exhausted'.
(Other definitions for flee that I've seen before include "rush" , "head for the hills" , "Run quickly away" , "Do a runner" , "Turn tail" .)