Escape from a scuffle, exhausted (4)
I believe the answer is:
flee
'escape' is the definition.
(I've seen this in another clue)
'from a scuffle exhausted' is the wordplay.
'from' indicates a hidden word.
'FLEE' is hidden within 'scuffle exhausted'.
(Other definitions for flee that I've seen before include "rush" , "head for the hills" , "Run quickly away" , "Do a runner" , "Turn tail" .)