Europeans disturbed by news on international lack of interest (5)
I believe the answer is:
ennui
'lack of interest' is the definition.
(I've seen this in another clue)
'europeans disturbed by news on international' is the wordplay.
'europeans' becomes 'eu' (I can't justify this - if you can you should give a lot more credence to this answer).
'disturbed by' means one lot of letters goes inside another (inserted letters disrupt or disturb the word).
'news' becomes 'nn' (the abbreviation for 'new' written twice).
'on' means one lot of letters go next to another.
'international' becomes 'i' (abbreviation eg in IMF).
'eu' placed around 'nn' is 'ennu'.
'ennu'+'i'='ENNUI'
Can you help me to learn more?
(Other definitions for ennui that I've seen before include "doldrums" , "Result of boredom" , "Weary feeling" , "Listless boredom" , "Effect of boredom" .)