Girl out of breath? (6)
I believe the answer is:
bertha
'girl' is the definition.
'of breath?' is the wordplay.
'of' indicates anagramming the letters (the answer comes from or 'of' the letters).
'breath' with letters rearranged gives 'BERTHA'.
'out' is the link.
(Other definitions for bertha that I've seen before include "collar" , "Woman's name" , "big woman?" , "The bar (anag.)" , "Girl's name - big German WWI gun" .)