Great ---, dog breed (4)
I believe the answer is:
dane
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">great dog breed</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this in another clue)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for dane that I've seen before include "Great - - , dog" , "Eg, Hamlet" , "Hamlet, say" , "invader once" , "Scandinavian" .)