Great sorrow (3)
I believe the answer is:
woe
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">great sorrow</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this before)</span><br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for woe that I've seen before include "Misery - tribulation" , "Archaic sorrow or grief" , "Misery, wretchedness" , "Alas!" , "Grief, misery" .)