Great sorrow or distress (3)
I believe the answer is:
woe
<span class="explanation-format__ClueExplanation">This clue is a double definition.<br/ ><br/ >'<span class="explanation-format__original">great sorrow</span>' is the first definition.<br/ ><span class="explanation-format__explanation">(I've seen this in another clue)</span><br/ ><br/ >'<span class="explanation-format__original">distress</span>' is the second definition.<br/ ><span class="explanation-format__explanation">(I've seen this in another clue)</span><br/ ><br/ ></span>
(Other definitions for woe that I've seen before include "Tale content?" , "Trouble" , "Difficulty" , "'Wednesday's child is full of ...'" , "Misfortune" .)