Having acquired knowledge about home working (2,2)
I believe the answer is:
in on
'having acquired knowledge' is the definition.
I know nothing about this answer so I cannot judge whether it can be defined by this definition.
'home working' is the wordplay.
'home' becomes 'in' ('he's home' can mean 'he's in').
'working' becomes 'on' (on can mean working or activated).
'in'+'on'='IN ON'
'about' acts as a link.
Can you help me to learn more?
(Other definitions for in on that I've seen before include "Participating in - knowing about" , "Wise to" , "Aware of - being part of" , "Privy to" , "Aware of secret" .)