Highly original form of male sin (7)
I believe the answer is:
seminal
'highly original' is the definition.
(I've seen this in another clue)
'form of male sin' is the wordplay.
'form of' is an anagram indicator (another form of the same letters).
'male'+'sin'='malesin'
'malesin' with letters rearranged gives 'SEMINAL'.
(Other definitions for seminal that I've seen before include "Of seed, or giving rise to new developments" , "Majorly influential" , "Menials (anag) - creative" , "Highy important" , "Major" .)