Hopelessness (7)
I believe the answer is:
despair
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">hopelessness</span>' is the definition.<br/ ><span class="explanation-format__explanation">(despair is a kind of hopelessness)</span><br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for despair that I've seen before include "Be without hope" , "Give up hope" , "First appearance" , "Smashed up" , "Abandon hope" .)