Impudence — annoy (4)
I believe the answer is:
gall
<span class="explanation-format__ClueExplanation">I believe this is a double definition.<br/ ><br/ >'<span class="explanation-format__original">impudence</span>' is the first definition.<br/ ><span class="explanation-format__explanation">(synonyms)</span><br/ ><br/ >'<span class="explanation-format__original">annoy</span>' is the second definition.<br/ ><span class="explanation-format__explanation">(gall can mean to annoy)</span><br/ ><br/ ></span>
(Other definitions for gall that I've seen before include "Audacity" , "A sore spot or a bodily bladder" , "Spleen or brass neck" , "Brass nedk or bile" , "Bitterness of feeling or bodily bladder" .)