Crossword Genius

In SE Milan, somehow seedy, in a sense (7)

Ross

I believe the answer is:

seminal

I'm a little stuck... Click here to teach me more about this clue!

'in' is the definition.
Both the definition and answer are adjectives. Maybe there's a link between them I don't understand?

'se milan somehow seedy in a sense' is the wordplay.
'se milan' anagrams to 'SEMINAL'.
Though, I'm not sure how this is indicated.

Can you help me to learn more?

(Other definitions for seminal that I've seen before include "Generating new developments for menials" , "Original and influential" , "Having strong later influence" , "Majorly influential" , "Strongly influential" .)

I've seen this clue in the Evening Standard.
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