In the best position not to struggle to go to work (2,3)
I believe the answer is:
on top
'in the best position' is the definition.
I know nothing about this answer so I can't tell whether this works.
'not to struggle to go to work' is the wordplay.
I cannot really understand how this works, but
an anagram of 'not' is 'ont' which is within the answer.
'work' could be 'op' (abbreviation for opus) and 'op' is located in the answer.
No letters remain.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for on top that I've seen before include "Leading" , "Winning" , "In a dominant position" , "At the summit or in superior position" .)