Loaded fellow going to space (5)
I believe the answer is:
laden
'loaded' is the definition.
(synonyms)
'fellow going to space' is the wordplay.
'fellow' becomes 'lad' (synonyms).
'going to' is a charade indicator (letters next to each other).
'space' becomes 'en' (in printing, a space as wide as a letter 'n').
'lad'+'en'='LADEN'
(Other definitions for laden that I've seen before include "Carrying a load" , "Eland (anag)" , "Loaded - oppressed" , "charged a lot" , "Loaded with cargo or burden" .)