Marlene and her twin share pipe cleaner (5)
I believe the answer is:
enema
'cleaner' is the definition.
(thesaurus)
'marlene and her twin share pipe' is the wordplay.
I cannot really see how this works, but
'and' could be 'n' (common abbreviation for 'and') and 'n' is located in the answer.
'her' could be 'ema' and 'ema' is present in the answer.
A single letter 'e' remains which might be clued in a way I don't see.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for enema that I've seen before include "Medical liquid introduced anally" , "Stern action from nurse perhaps" , "In the end medical procedure" , "Rectal medicine" , "process to ensure evacuation" .)