Reportedly ready for American anguish (6)
I believe the answer is:
dolour
'anguish' is the definition.
(I've seen this before)
I can't explain the remainder of the clue.
Can you help me to learn more?
(Other definitions for dolour that I've seen before include "Woe" , "Grief" , "In distress" , "sadness" , "Anguish" .)