Rise beginning to affect Cologne? (6)
I believe the answer is:
ascent
'rise' is the definition.
(synonyms)
'beginning to affect cologne?' is the wordplay.
'beginning to' suggests taking the first letters.
'cologne?' becomes 'scent' (cologne is a type of scent).
The initial letter of 'affect' is 'a'.
'a'+'scent'='ASCENT'
(Other definitions for ascent that I've seen before include "Enacts in climb" , "A rise in status; climb" , "Upward movement" , "Maybe promotion" , "rising?" .)