Setback (8)
I believe the answer is:
reversal
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">setback</span>' is the definition.<br/ ><span class="explanation-format__explanation">(synonyms)</span><br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for reversal that I've seen before include "Volte-face" , "that doesn't affect mum or dad" , "Turnaround - defeat" , "A change to an opposite direction" , "About-turn" .)