Stop on the way (4)
'stop' is the definition.
(to take a rest is to stop)
'on the way' is the wordplay.
'on' becomes 're' (regarding).
'the way' becomes 'st' (abbreviation for street).
're'+'st'='REST'
(Other definitions for rest that I've seen before include "Surplus" , "Change is as good as this, they say" , "'Relax, pause from work (4)'" , "Leisure" , "Pole in Crucible?" .)
(Other definitions for motel that I've seen before include "Kind of hostelry for car drivers" , "Place to stay when driving" , "Rented accommodation" , "place for the rest of the travellers" , "lodging-place" .)