Struggle with gender reassignment - following one that doesn't look great (6)
I believe the answer is:
scruff
'struggle with gender reassignment following one that doesn't look great' is the definition.
Although both the answer and definition are singular nouns, I don't see how one could define the other.
'following one that doesn't look great' is the wordplay.
I cannot quite see how this works, but
'following' could be 'ff' (abbreviation used in citations) and 'ff' is present in the answer.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for scruff that I've seen before include "The back side of the neck" , "Back of a cat's neck" , "Back of the neck of, say, cat" , "One probably wouldn't wash" , "Nape; untidy type" .)