Suffer in a detached way (4)
I believe the answer is:
ache
'suffer' is the definition.
(synonyms)
'in a detached way' is the wordplay.
'in' indicates the answer is hidden within the clue.
'ACHE' is hidden within 'detached way'.
(Other definitions for ache that I've seen before include "Shakespearean character" , "Continuous hurt" , "Pine" , "suffering" , "Each (anag.)" .)