There's nothing in a half bottle to give you a kick (4)
I believe the answer is:
boot
'a kick' is the definition.
('boot' can be a synonym of 'kick')
'there's nothing in a half bottle' is the wordplay.
'there's nothing' becomes 'o' (I've seen this in other clues).
'in' means one lot of letters goes inside another.
'a half' indicates taking half.
'bottle' cut in half is 'bot'.
'o' placed into 'bot' is 'BOOT'.
'to give you' is the link.
(Other definitions for boot that I've seen before include "Clothing; kick" , "Item of footwear" , "Luggage compartment" , "Heavy footwear" , "may be packed for a journey" .)