Travel to ancient city with one manuscript from the East (7)
I believe the answer is:
tourism
'travel' is the definition.
(travelling to different places)
'to ancient city with one manuscript from the east' is the wordplay.
'ancient city' becomes 'ur' (ancient Sumerian city state).
'with' is a charade indicator (letters next to each other).
'one' becomes 'i' (Roman numeral).
'manuscript' becomes 'ms' (abbreviation for manuscript).
'from the east' says the letters should be written in reverse (on a map from right to left).
'ms' back-to-front is 'sm'.
'to'+'ur'+'i'+'sm'='TOURISM'
(Other definitions for tourism that I've seen before include "The business of providing services to visitors" , "going places" , "leave business?" , "Holiday visits" , "Industry involved in attracting and servicing visitors" .)