Vicissitudes (3,3,5)
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">vicissitudes</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this before)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for ups and downs that I've seen before include "Successes and failures" , "variations?" , "Vicissitudes" .)