Well-informed American went over instruction to read more (2,2,5)
I believe the answer is:
up to speed
'well-informed' is the definition.
(I've seen this in another clue)
'american went over instruction to read more' is the wordplay.
I cannot really see how this works, but
'went' could be 'peed' (both can mean urinated) and 'peed' is found within the answer.
'over' could be 'up' (e.g. if your time is up it is over) and 'up' is located in the answer.
'to' is within the answer.
A single letter 's' remains which might be clued in a way I don't understand.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for up to speed that I've seen before include "fully informed" , "at full pace" , "In the know" .)