A cat means very little (4)
I believe the answer is:
atom
'very little' is the definition.
'atom' can be an answer for 'little' (thesaurus). I am not sure about the 'very' bit.
'a cat' is the wordplay.
'cat' becomes 'tom' (a tom is a male cat).
'a'+'tom'='ATOM'
'means' acts as a link.
Can you help me to learn more?
(Other definitions for atom that I've seen before include "Part of molecule" , "Neutron and proton" , "Smallest unit of matter" , "A mighty particle, can be explosive" , "Nucleus plus electrons" .)