Accept Kate is different (4)
I believe the answer is:
take
'accept' is the definition.
(taking is a kind of accepting)
'kate is different' is the wordplay.
'is different' indicates anagramming the letters.
'kate' is an anagram of 'TAKE'.
(Other definitions for take that I've seen before include "Subtract; assume" , "film sequence" , "Endure; single recording" , "Convey; consume" , "Remove, subtract" .)