Crossword Genius

… affected American college centre (6)

Ross

I believe the answer is:

campus

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Here is my best explanation:

'college centre' is the definition.
(site of a college or university)

'affected american' is the wordplay.
'affected' becomes 'camp' (I've seen this before).
'american' becomes 'us' (abbreviation for United States).
'camp'+'us'='CAMPUS'

Ross

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This clue was last seen in The Independent

(Other definitions for campus that I've seen before include "University buildings and grounds", "College estate", "buildings in Nottingham, say", "The grounds of a university", "educational grounds", "In study area", "University area", "student quarters", "educational location" and "academic haunt".)

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