After 50, single lady losing heart … may feel this? (6)
I believe the answer is:
Here is my best explanation:
'feel this?' is the definition.
The definition suggests a singular noun but the answer is not.
'after 50 single lady losing heart' is the subsidiary indication.
'after' is a charade indicator (letters next to each other).
'50' becomes 'l' ('l' can be a synonym of '50').
'single' becomes 'one' ('one' can be a synonym of 'single').
'losing heart' says to hollow out the word (remove centre letters).
'lady' with its middle taken out is 'ly'.
'l' put next to 'one' is 'lone'.
'may' is the link.
(Other definitions for lonely that I've seen before include "... in need of company ...", "Lacking companionship", "Without companionship", "Unfrequented", "Forlorn, solitary", "Without companions", "In want of company", "Short of companionship", "From the beginning (Latin)" and "Lacking company".)