All the changes of a deadly nature (6)
I believe the answer is:
lethal
'of a deadly nature' is the definition.
'all the changes' is the wordplay.
'changes' indicates anagramming the letters.
'all'+'the'='allthe'
'allthe' anagrammed gives 'LETHAL'.
(Other definitions for lethal that I've seen before include "Killing" , "bringing down the curtain" , "Deadly, potentially fatal" , "Noxious" , "Deadly dangerous" .)