Annoy if coming between the sexes (4)
I believe the answer is:
miff
'annoy' is the definition.
(I've seen this before)
'if coming between the sexes' is the wordplay.
'coming between' indicates putting letters inside.
'the sexes' becomes 'mf' (I can't explain this - if you can you should give a lot more credence to this answer).
'if' put within 'mf' is 'MIFF'.
Can you help me to learn more?
(Other definitions for miff that I've seen before include "causes resentment" , "Put in a bad mood" , "Annoy - offend" , "Take offence" , "minor quarrel" .)