At home, aggressive dog makes one suffer (5)
I believe the answer is:
incur
'one suffer' is the definition.
(I've seen this before)
'at home aggressive dog' is the wordplay.
'at home' becomes 'in' ('in' can be similar in meaning to 'at home').
'aggressive dog' becomes 'cur' (I've seen this before).
'in'+'cur'='INCUR'
'makes' is the link.
(Other definitions for incur that I've seen before include "Bring something on oneself, often unpleasant" , "Become subject to (something unwelcome)" , "Meet" , "Risk" , "Fall into - invite" .)