At work, Sue, Ned and Edward like some grapes? (8)
I believe the answer is:
unseeded
'like some grapes?' is the definition.
'at work sue ned and edward' is the wordplay.
'at work' indicates an anagram.
'and' means one lot of letters go next to another.
'edward' becomes 'ed'.
'sue'+'ned'='suened'
'suened' is an anagram of 'unseed'.
'unseed'+'ed'='UNSEEDED'
(Other definitions for unseeded that I've seen before include "Not among top players in a tennis tournament" , "Players of lesser skill, in tennis say" , "Not expected to succeed at Wimbledon" , "not prepared for grass, say" .)