Awkward tone about female regularly (5)
I believe the answer is:
often
'regularly' is the definition.
(thesaurus)
'awkward tone about female' is the wordplay.
'awkward' indicates anagramming the letters.
'about' means one lot of letters goes inside another.
'female' becomes 'f' (abbreviation).
'tone' is an anagram of 'oten'.
'oten' placed around 'f' is 'OFTEN'.
(Other definitions for often that I've seen before include "occurring with frequency" , "A great deal" , "on numerous occasions" , "Frequently, habitually" , "Multiply" .)