Beer with new king in joint (5)
I believe the answer is:
ankle
'joint' is the definition.
(ankle is a kind of joint)
'beer with new king' is the wordplay.
'beer' becomes 'ale' (I've seen this before).
'with' is an insertion indicator.
'new' becomes 'n'.
'king' becomes 'k'.
'n'+'k'='nk'
'ale' placed around 'nk' is 'ANKLE'.
'in' acts as a link.
(Other definitions for ankle that I've seen before include "Joint between foot and leg" , "Lower leg joint" , "Foot-leg connector" , "Major foot joint" , "Narrow part of leg" .)