Bone setter got up in mink? (5)
I believe the answer is:
femur
'bone' is the definition.
(femur is a kind of bone)
'setter got up in mink?' is the wordplay.
'setter' becomes 'me' (the setter of the clue).
'got up' shows that the letters should be reversed in order.
'in' means one lot of letters goes inside another.
'mink?' becomes 'fur' (mink is a kind of fur).
'me' back-to-front is 'em'.
'em' going inside 'fur' is 'FEMUR'.
(Other definitions for femur that I've seen before include "Bone in leg" , "Thighbone" , "Part of leg" , "Large bone" , "Longest bone in the human body" .)