Cancel Times before end of issue (5)
I believe the answer is:
erase
'cancel' is the definition.
(erasing is a kind of cancelling)
'times before end of issue' is the wordplay.
'times' becomes 'eras' (era is a kind of time).
'before' is a charade indicator (letters next to each other).
'end of' says to take the final letters.
The last letter of 'issue' is 'e'.
'eras'+'e'='ERASE'
(Other definitions for erase that I've seen before include "Eliminate" , "Scratch" , "Remove evidence of" , "Blank out" , "Take out" .)