Career crazily with son, guzzling new wine (8)
I believe the answer is:
Here is my best explanation:
'wine' is the definition.
'career crazily with son guzzling new' is the subsidiary indication.
'crazily' indicates an anagram.
'with' is an insertion indicator.
'son' becomes 's'.
'guzzling' indicates putting letters inside (I've seen this in other clues).
'new' becomes 'n' (**).
'career' with letters rearranged gives 'acerre'.
'acerre' placed around 's' is 'sacerre'.
'sacerre' placed around 'n' is 'sancerre'.
(Other definitions for sancerre that I've seen before include "A French white wine", "Wine", "Type of French white wine" and "Light French white wine".)