Charles and the Queen making a drink (6)
I believe the answer is:
chaser
'a drink' is the definition.
(thesaurus)
'charles and the queen' is the wordplay.
'charles' becomes 'chas' (shortened form).
'and' is a charade indicator (letters next to each other).
'the queen' becomes 'er' (Elizabeth Regina).
'chas'+'er'='CHASER'
'making' is the link.
(Other definitions for chaser that I've seen before include "Drink following another of a different kind" , "Pursuit cannon; one engraving" , "Beer after whisky - follow that!" , "A drink like beer after whisky" , "Beer after spirits e.g." .)