City of ancestral suffering (9)
I believe the answer is:
lancaster
'city' is the definition.
(Lancaster is an example)
'ancestral suffering' is the wordplay.
'suffering' indicates an anagram.
'ancestral' is an anagram of 'LANCASTER'.
'of' is the link.
(Other definitions for lancaster that I've seen before include "University" , "A rose-red city" , "WW2 aircraft; city" , "Duke" , "City in north-west England" .)