City of Rome spoilt, sadly (10)
I believe the answer is:
Here is my best explanation:
'city' is the definition.
('metropolis' can be a synonym of 'city')
'rome spoilt sadly' is the subsidiary indication.
'sadly' indicates anagramming the letters.
'romespoilt' is an anagram of 'metropolis'.
'of' is the link.
(Other definitions for metropolis that I've seen before include "Chief city", "Very large city", "Major city of region", "Big city" and "Urban centre".)