City of Rome spoilt, sadly (10)
I believe the answer is:
metropolis
'city' is the definition.
('metropolis' can be a synonym of 'city')
'rome spoilt sadly' is the wordplay.
'sadly' indicates an anagram.
'rome'+'spoilt'='romespoilt'
'romespoilt' anagrammed gives 'METROPOLIS'.
'of' is the link.
(Other definitions for metropolis that I've seen before include "Main city" , "Chief city" , "Very large city" , "London, say" , "capital" .)