Comfortable with arms raised (4)
I believe the answer is:
snug
'comfortable' is the definition.
(similar in meaning)
'arms raised' is the wordplay.
'arms' becomes 'guns ' (gun is a kind of arm).
'raised' shows that the letters should be reversed in order (going up in a down clue).
'guns' backwards is 'SNUG'.
'with' is the link.
(Other definitions for snug that I've seen before include "Cosy retreat" , "Comfy and cosy like bug in rug" , "Comfortabel with guns" , "Bar parlour - comfortably placed" , "Cosy and comfortable" .)