Depressed in fights when the wheels come off?

'the wheels come off?' is the definition.
I know nothing about this answer so I cannot tell whether this works.

'depressed in fights' is the wordplay.
'depressed' becomes 'low' ('low' can be a synonym of 'depressed').
'in' means one lot of letters goes inside another.
'fights' becomes 'bouts' ('bout' can be a synonym of 'fight').
'low' going into 'bouts' is 'BLOW-OUTS'.

'when' acts as a link.

Can you help me to learn more?