Difficult turn in the road, perhaps, for us (7)
I believe the answer is:
arduous
'difficult' is the definition.
(I've seen this in another clue)
'turn in the road perhaps for us' is the wordplay.
'turn' becomes 'u' (a 'U-turn' is a kind of turn).
'in the' means one lot of letters goes inside another.
'perhaps' indicates anagramming the letters.
'for' says to put letters next to each other.
'road' with letters rearranged gives 'ardo'.
'u' placed into 'ardo' is 'arduo'.
'arduo'+'us'='ARDUOUS'
(Other definitions for arduous that I've seen before include "Punishing" , "Requiring great effort" , "Tough" , "Demanding great effort" , "Gruelling, strenuous" .)