Doctor Galen with niece: not Grace? (10)

I believe the answer is:

inelegance

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'grace?' is the definition.
The answer and definition can be both human attributes as well as being singular nouns.
Perhaps there's a link between them I don't understand?

'doctor galen with niece' is the wordplay.
'doctor' is an anagram indicator.
'with' is a charade indicator (letters next to each other).
'galen' after 'niece' is 'niecegalen'.
'niecegalen' is an anagram of 'INELEGANCE'.

'not' is the link.

Can you help me to learn more?

(Another definition for inelegance that I've seen is " Lack of refinement".)

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