Drug Republican from Rome, possibly, ignoring American (7)
I believe the answer is:
ritalin
'drug' is the definition.
(I've seen this before)
'republican from rome possibly ignoring american' is the wordplay.
I cannot quite understand how this works, but
'republican' could be 'r' (abbreviation in US politics) and 'r' is found within the answer.
'from' could be 'in' (I've seen this in other clues) and 'in' is present in the answer.
'american' could be 'a' (common abbreviation - e.g. in organisation names) and 'a' is located in the answer.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for ritalin that I've seen before include "stimulant" , "Drug" .)